Our team of expert biological curators, augmented by computational tools, maintain and enhance a knowledge extraction and refinement process that delivers an ever-growing set of relevant biological data and its provenance.
We develop and promote the use of shared ontologies to describe knowledge in an open and extensible model that is targeted towards machine reasoning. We develop, adapt and apply innovative scientific knowledge management theory and technology to provide computational semantic bridges between disparate knowledge sources.
We seek to enable bioinformatic reasoning and clinical decision-making using all the species as well as associated bioinformatic data, including genes, phenotypes, chemistry, drugs, and much more.
Much of science is focused on specific diseases, anatomical systems, or data types. The Translational and Integrative Sciences Laboratory (Tislab), led by Dr. Melissa Haendel, uses semantic technologies to integrate data across disciplinary divides. Such systems have been used to leverage model organism data for rare disease diagnostics, to identify new disease genes, and to reveal potential drug targets. The Tislab also develops global standards that aid such integration and data sharing, such as the Phenopackets standard for patient phenotype data sharing, and the Mondo ontology for harmonizing how we define diseases for use in global diagnostic tools. Integration of environmental exposure and dietary data is key to predicting and altering disease course, and the Tislab is actively engaged in supporting the combined analysis of genomic and other molecular data with patient surveys. Tislab’s ultimate goal is to weave together basic laboratory research, environmental and dietary, and genomic data along with patient generated data to realize collaborative health.
Director of the Translational and Integrative Sciences Laboratory
Director of Translational Data Science at OSU
Director of the Center for Data to Health at OHSU
Associate Professor in the OSU Department of Environmental Toxicology and in the OHSU Department of Medical Informatics and Clinical Epidemiology
Principal Investigator at the OSU Linus Pauling Institute and Center for Genome Research and Biocomputing
Our core team is based in the beautiful Pacific Northwest at two powerful institutions: Oregon State University and Oregon Health and Sciences University.
Our research facilities are located in the Center for Genome Research and Biocomputing (CGRB) on the Oregon State University campus in the Linus Pauling Institute
Our Oregon Health & Science University research facilities are located at OCTRI in the School of Nursing.
